Studies of insulin resistance in patients with clinical and subclinical hyperthyroidism

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Studies of insulin resistance in patients with clinical and subclinical hyperthyroidism.

OBJECTIVE Although clinical hyperthyroidism (HR) is associated with insulin resistance, the information on insulin action in subclinical hyperthyroidism (SHR) is limited. DESIGN AND METHODS To investigate this, we assessed the sensitivity of glucose metabolism to insulin in vivo (by an oral glucose tolerance test) and in vitro (by measuring insulin-stimulated rates of glucose transport in iso...

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Studies of insulin resistance in patients with clinical and subclinical hypothyroidism.

OBJECTIVE Although clinical hypothyroidism (HO) is associated with insulin resistance, there is no information on insulin action in subclinical hypothyroidism (SHO). DESIGN AND METHODS To investigate this, we assessed the sensitivity of glucose metabolism to insulin both in vivo (by an oral glucose tolerance test) and in vitro (by measuring insulin-stimulated rates of glucose transport in iso...

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Effect of insulin resistance in assessing the clinical outcome of clinical and subclinical hypothyroid patients.

BACKGROUND The effect of thyroid status on insulin sensitivity is of great interest but despite various studies there is conflicting data on this subject. Hypothyroidism has been associated with disorders of glucose and insulin metabolism involving defective insulin secretion in response to glucose, hyperinsulinemia, altered peripheral glucose disposal and insulin resistance. Thyroid dysfunctio...

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Clinical and therapeutic controversies on subclinical hyperthyroidism

Subclinical hyperthyroidism is defined as low or undetectable serum thyrotropin concentration in the presence of levels of free thriiodothyronine and thyroxine within the reference range. Despite the conflicting results from many observational studies, this thyroid disorder has been associated with an increased risk of developing atrial fibrillation, left ventricular hypertrophy, increased hear...

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ژورنال

عنوان ژورنال: European Journal of Endocrinology

سال: 2010

ISSN: 0804-4643,1479-683X

DOI: 10.1530/eje-10-0246